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Big Data and Biological Networks · Quiz 1 · Jan 2023

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Questions and published explanations below are available without starting a test. Some questions may not have a published solution yet.

Question 141 MCQ · 1.0 marks

What kind of functional genomics approach would you choose if you are interested in the study of how histone methylation regulates gene expression?
  1. RNA-Seq
  2. Transcriptomics
  3. Epigenomics
  4. Metabolomics

A published solution is not available for this question yet.

Question 142 MCQ · 1.0 marks

Which **one** of the following is **untrue** about DNA sequencing methods?
  1. Purified fragments of DNA cut from plasmid/phage clones or amplified by polymerase chain reaction (PCR)
  2. Clones of DNA fragments are denatured to single strands, and one of the strands is hybridized to an oligonucleotide primer
  3. Reverse transcriptase is used to create DNA fragments during DNA sequencing
  4. New strands of DNA are synthesized from the end of the primer

A published solution is not available for this question yet.

Question 143 MCQ · 1.0 marks

A major design consideration in a microarray experiment is the incorporation of replicates. Which **one** of the following statements is most appropriate in stating the consequence(s) of not including replicates in your experiment?
  1. The number of false-positive errors in detecting differentially expressed genes will increase
  2. The number of false-negative errors in detecting differentially expressed genes will increase
  3. No statistical analysis of the significance of the observed changes will be possible
  4. All of these

A published solution is not available for this question yet.

Question 144 MCQ · 1.0 marks

Imagine you are designing an experiment to measure gene expression in the blood of patients who have been treated with a new drug. You want to measure expression of all genes in the genome and may want to use the data to identify novel transcripts (e.g. miRNAs) in the future. Which method would you choose?
  1. Real-time PCR
  2. ChiP-seq
  3. Microarray analysis
  4. RNA-seq

A published solution is not available for this question yet.

Question 145 MCQ · 1.0 marks

In a RNA-seq experiment, which file contains raw sequence data?
  1. SAM file
  2. BAM file
  3. FASTQ file
  4. CRAM file

A published solution is not available for this question yet.

Question 146 MCQ · 1.0 marks

Which one of the following is most appropriate option?
  1. Frameshift mutation involves the insertion or deletion of a single base in a DNA molecule
  2. Mutagen is a substance or energy form that can cause a mutation in DNA
  3. Point Mutation involves substitution of a single nucleotide in a DNA molecule
  4. Frameshift mutation involves the insertion or deletion of a single base in a DNA molecule, Mutagen is a substance or energy form that can cause a mutation in DNA and Point Mutation involves substitution of a single nucleotide in a DNA molecule
  5. None of these

A published solution is not available for this question yet.

Question 147 MCQ · 1.0 marks

In a DNA molecule, which molecules make up the backbone of the double helix?
  1. Single nucleotides
  2. Joined sugar and phosphates
  3. Joined nitrogenous base and phosphates
  4. Paired nucleotides

A published solution is not available for this question yet.

Question 148 MCQ · 1.0 marks

Which of the following accounts for the inability of dideoxynucleotide triphosphates (ddNTPs) to further polymerize in Sanger DNA sequencing?
  1. Lack of a hydroxyl group on the 2' carbon
  2. Lack of a hydroxyl group on the 3' carbon
  3. Lack of a triphosphate moiety on the 5' carbon
  4. Presence of a hydroxyl group on the 3' carbon

A published solution is not available for this question yet.

Question 149 MCQ · 1.0 marks

A connected graph is said to have an Eulerian path if it has zero or two vertices with odd degrees. Given the degree distribution of the two connected graphs, Graph-A and Graph-B, find if any of the graphs has the Eulerian path. [[IMAGE:6e8f307fb5f32bc9_6_3]]
Source diagram or notation
  1. Only Graph A
  2. Only Graph B
  3. Both Graph A and Graph B
  4. Neither of them

A published solution is not available for this question yet.

Question 150 MCQ · 1.0 marks

What value of p for an Erdos-Renyi network G(n,p), would generate a random network comparable to a regular lattice with n=25 and k=3?
  1. 0.125
  2. 0.25
  3. 0.40
  4. 0.50

A published solution is not available for this question yet.

Question 151 MCQ · 1.0 marks

Let ‘**A**’ denote the adjacency matrix of a graph, and ‘n’ denote the number of non-zero elements in ‘ **A**’. Which one of the following is true?
  1. If A represents an undirected graph, then n is always an even number
  2. If A represents a directed graph, then n is always an even number
  3. If self-loops are allowed, then n is always an even number
  4. In a weighted graph, the sum of all the elements in A equals n

A published solution is not available for this question yet.

Question 152 MCQ · 1.0 marks

Density of the below-given graph is: [[IMAGE:6e8f307fb5f32bc9_8_4]]
Source diagram or notation
  1. 0.52
  2. 0.7
  3. 0.43
  4. 0.23

A published solution is not available for this question yet.

Question 153 MCQ · 1.0 marks

Which of the following are true about the regular graph?
  1. It is a connected graph
  2. The degree distribution of the graph follows the binomial distribution
  3. The clustering coefficient is the same for all the nodes
  4. The number of neighbours for all the nodes remains the same

A published solution is not available for this question yet.

Question 154 MCQ · 1.0 marks

There are four connected components in a graph of 10 nodes. The number of nodes in each of them is 2,2,3 and 3. What is the minimum number of possible edges in the graph?
  1. 3
  2. 10
  3. 8
  4. 6

A published solution is not available for this question yet.

Question 155 MCQ · 1.0 marks

How many edges does a complete bipartite graph with 10 nodes (each group have 5 nodes) have?
  1. 45
  2. 55
  3. 35
  4. 25

A published solution is not available for this question yet.

Question 156 MCQ · 1.0 marks

If a graph has 25 vertices and a minimum degree of 5, what is the maximum number of edges it can have?
  1. 300
  2. 400
  3. 100
  4. 200

A published solution is not available for this question yet.

Question 157 MCQ · 1.0 marks

In the preferential attachment model, new incoming node would attach to the nodes 1,2,3,4 in the network below with the following probabilities: [[IMAGE:6e8f307fb5f32bc9_10_5]]
Source diagram or notation
  1. 1/4, 1/4, 1/4, 1/4
  2. 3/4, 2/4, 2/4, 1/4
  3. 1/8, 1/8, 1/8, 1/8
  4. 3/8, 2/8, 2/8, 1/8

A published solution is not available for this question yet.

Question 158 MCQ · 1.0 marks

In a graph of 23 nodes and 50 edges, the average degree is:
  1. 2.17
  2. 4.35
  3. 0.92
  4. 1.24

A published solution is not available for this question yet.

Question 159 MCQ · 1.0 marks

[[IMAGE:6e8f307fb5f32bc9_11_6]]
Source diagram or notation
  1. (1,2)
  2. (1,2), (2,1), (1,1), (2,2)
  3. (1,2), (1,1), (2,2)
  4. (1,2), (2,1)

A published solution is not available for this question yet.

Question 160 MSQ · 2.0 marks

Through proteomics studies, which of the following research-questions can be addressed. Select all the correct options.
  1. Is the abundance of the tumour suppressor p-53 affected by growth of a human cell line in the presence of penicillin?
  2. Which genes are upregulated in response to lower temperatures in a culture of S. cerevisiae?
  3. Which proteins are localised to the Golgi apparatus in mouse liver hepatocytes?
  4. Which SNPs are associated with Breast Cancer?

A published solution is not available for this question yet.

Question 161 MSQ · 2.0 marks

Which of the following are the application of metabolomics. Select all the correct options.
  1. Identification of disease biomarkers
  2. Mass production of essential proteins and metabolites
  3. Determination of SNPs associated with a disease
  4. To study gene-expression pattern in a context-specific manner

A published solution is not available for this question yet.

Question 162 MSQ · 2.0 marks

Which of the following are true for Illumina sequencing? Select all the correct options.
  1. Sequence a single DNA fragment at a time
  2. Short fragment reads (100-150 bp) are ligated to the flow cell surface
  3. Ability to sequence hundreds to thousands of genes or gene regions simultaneously
  4. None of these

A published solution is not available for this question yet.

Question 163 MSQ · 2.0 marks

Let ‘**A**’ be the adjacency matrix of a fully connected bi-partite graph with seven nodes. Five nodes belong to one group, and the other two belong to the other. The matrix ‘**A**’ has rows and columns arranged so that the first five rows (and columns) denote the nodes from one particular group. Let n be the number of non-zero elements in the graph. Which of the following are true? Select all the correct options.
  1. The maximum value of n is 20
  2. n is always an even number
  3. The number of non-zero elements in A[:5 , :5] is 10
  4. The minimum value of n is 10

A published solution is not available for this question yet.

Question 164 MSQ · 2.0 marks

Which of the following are not an example of a biological network? Select all the correct options.
  1. Metabolic network
  2. Citation network from a biological journal
  3. Signaling network
  4. People from a Facebook group “Big data in biology”

A published solution is not available for this question yet.

Question 165 MSQ · 2.0 marks

Which of the following are true statements. Select all the correct options.
  1. Number of parameters required for generating a Erdos-Renyi graph is 2
  2. Number of parameters required for generating a Watts-Strogatz graph is 3
  3. Number of parameters required for generating a power-law graph is 1
  4. Neither of them are correct

A published solution is not available for this question yet.

Question 166 MSQ · 2.0 marks

Which of the following are true about the Watts-Strogatz network? Select all the correct options.
  1. It can capture the degree distribution of the real-world network
  2. It can capture the small-world properties of the real-world network
  3. It has a long-tail degree distribution
  4. It can capture the characteristic path length of the real-world network

A published solution is not available for this question yet.

Question 167 MSQ · 2.0 marks

Which of the following are true for RNA-seq studies? Select all the correct options.
  1. Bulk RNA-seq captures only an “average” of the expression profiles of thousands of cells
  2. Single cell RNA-seq (scRNA-seq) allows the capture of individual measurements across dozens and up to thousands of single cells
  3. RNA transcripts generated are identical across all the cell-types.
  4. Post-translational modifications can be studied using RNA-seq approach.

A published solution is not available for this question yet.

Question 168 MSQ · 3.0 marks

Which of the following are correct for Multi-omics studies? Select all the correct options.
  1. It combines genomic data with data from other modalities such as transcriptomics, epigenetics, and proteomics
  2. It enables a more comprehensive understanding of molecular changes contributing to normal development, cellular response, and disease
  3. It focuses on one aspect of the biological system
  4. It allows the systematic understanding of information flow across different omics layers

A published solution is not available for this question yet.

Question 169 MSQ · 3.0 marks

Which of the following are true about GWAS studies? Select all the correct options.
  1. GWAS test hundreds of thousands of genetic variants across many genomes to find those statistically associated with a specific trait or disease
  2. GWAS can be used to predict an individual’s risk for physical and mental disease based on their genetic profile
  3. If a variant is found to be associated with a trait, it means that a variant in that genomic region **may** cause a difference in the trait
  4. If a variant is found to be associated with a trait, it means that a variant in that genomic region **certainly** causes a difference in the trait

A published solution is not available for this question yet.

Question 170 MSQ · 3.0 marks

Which of the following are true statements. Select all the correct options.
  1. Nanopore is long read sequencing technique, whereas, Illumina sequencing is short read sequencing technique.
  2. Nanopore has 99% accuracy whereas Illumina has 92-95% accuracy
  3. Nanopore sequencing technology uses change in current in protein nanopore when DNA is passed through it
  4. Illumina sequencing uses reversible dye terminator technology to detect the sequence of DNA molecules

A published solution is not available for this question yet.

Question 171 MCQ · 3.0 marks

Calculate the betweenness centrality of node ‘**3**’ in the given below network. [[IMAGE:6e8f307fb5f32bc9_17_7]]
Source diagram or notation
  1. 0.597
  2. 0.041
  3. 0.055
  4. 0.122

A published solution is not available for this question yet.

Question 172 MCQ · 3.0 marks

The average clustering coefficient of the given network is [[IMAGE:6e8f307fb5f32bc9_18_8]]
Source diagram or notation
  1. 0.66
  2. 0.33
  3. 0.86
  4. 0.46       **Fin Forensics** **Section Id :** 64065330381 **Section Number :** 10 **Section type :** Online **Mandatory or Optional :** Mandatory **Number of Questions :** 23 **Number of Questions to be attempted :** 23 **Section Marks :** 25 **Display Number Panel :** Yes **Group All Questions :** No **Enable Mark as Answered Mark for Review and** Yes **Clear Response :** **Maximum Instruction Time :** 0

A published solution is not available for this question yet.